Eradic8 Bi-Oxy Proves Effective Against Clostridium Difficile
17th April 2007
Clostridium difficile caused more than 44,000 infections in the UK in 2004 - mostly among the elderly.
Researchers found it can chop and change its genetic structure very easily - maximising its ability to neutralise attack by antibiotics.
The Sanger Institute study is published in Nature Genetics.
The researchers hope their work will aid the search for new treatments, vaccines, and diagnostic tests.
The emergence of bacteria resistant to many of the leading antibiotics is a major problem facing healthcare providers worldwide.
C. difficile is a particular problem, because it can only be treated with two antibiotics, metronidazole and vancomycin - and there is concern that these will also soon become ineffective.
Bigger threat than MRSA
The bug is now more prevalent, and causes more deaths than the notorious superbug MRSA.
It causes a range of diseases from antibiotic-associated diarrhoea to a life-threatening colon disease, called pseudomembranous colitis.
The Sanger team found that half of the genes in C. difficile are absent from four of its bacterial cousins, including species that cause botulism and tetanus.
The researchers also found great genetic variation even between different strains of the bug.
Most important, and unlike its nearest relatives, C. difficile can readily exchange genes and resistance elements.
Researcher Dr Mohammed Sebaihia said: "The genome of C. difficile is in a state of flux.
"More than 10% of the genome consists of mobile elements - sequences that can move from one organism to another - and this is how it has acquired genes that make it such an effective pathogen.
"It has gained an array of genes that make it resist antibiotics, help it to interact with, and thrive in, the human gut and help it to change its surface.
"This combination gives it a hugely impressive range of resources to help it prosper in humans."
C. difficile thrives in the absence of oxygen and can "hibernate" in adverse conditions by forming spores.
It is thought these spores are responsible for most human infections, and because they are highly resistant to most disinfection methods they are very difficult to eradicate, and can spread easily.
Recent independent laboratory tests have shown Eradic8 Bi-Oxy to be highly effective against this spore forming super bug. Bio-Oxy is a chlorine-free oxygen releasing disinfectant which enables it to rapidly alter the comfortable oxygen-absent conditions that C.difficile thrives so much in! This results in the rapid and effective eradication of C.Difficile and in fact other spore forming bugs.
European Standard Disinfectant test EN13704 requires a >log 3 reduction of spores in 60 minutes, Eradic8 Bi-Oxy passes this test in as little as 15 minutes.
Bi-Oxy is an extensively tested all-round disinfectant that readily and safely destroys all pathogenic organisms and super-bugs from MRSA to C. Difficile. The disinfectant product comes in handy pre-measured sachets that reaily dissolve when mixed with water for safe and accurate point of use dilution.
Just when you need it fast Bi-Oxy is ready to go!!!
So now there really is an answer to this higly infectious and pathogenic super-bug it's called Eradic8 Bi-Oxy!
